Article Dans Une Revue Journal of Infectious Diseases Année : 1984

Characteristics of Autoantibodies to Human Interferon in a Patient with Varicella-Zoster Disease

Résumé

A patient with varicella-zoster disease was found to have antibodies to human interferon. These antibodies included all IgG subclasses, showed a high combined affinity (average dissociation constant, 1O-1 1 M) , and were present in serum at a concentration of 10-9 M. The antibodies neutralized the activity of a series of human a-interferons prepared from recombinant DNA as well as that of naturally occurring mixtures of a-type interferon prepared by viral stimulation of human cells. Examination of the patient's lymphoid cells revealed normal production of interferon and normal expression of interferon receptors. Interferon from the patient's cells was neutralized by her serum. The neutralizing capacity of this serum was analyzed with regard to levels of interferon previously detected in patients with varicella-zoster infections.

To date, nine patients with antibody to human interferon [1] have been described [2-6]. In four instances the antibodies appeared before or without clinical administration of interferon. In this study we examined the nature of these antibodies in one patient with respect to their specificity and capacity to block the activity of circulating interferon. We also attempted to estimate what kind of threat such antibodies might pose to a functional interferon system.

The patient studied (designated patient VZ) [3]

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hal-04926902 , version 1 (03-02-2025)

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Bruno Pozzetto, K. Mogensen, M. Tovey, I. Gresser. Characteristics of Autoantibodies to Human Interferon in a Patient with Varicella-Zoster Disease. Journal of Infectious Diseases, 1984, 150 (5), pp.707-713. ⟨10.1093/infdis/150.5.707⟩. ⟨hal-04926902⟩
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