Article Dans Une Revue Open Forum Infectious Diseases Année : 2023

Age Differences in Comorbidities, Presenting Symptoms, and Outcomes of Influenza Illness Requiring Hospitalization: A Worldwide Perspective From the Global Influenza Hospital Surveillance Network

Melissa Andrew
Henrique Pott
  • Fonction : Auteur
Justin Ortiz
  • Fonction : Auteur
John Mccauley
  • Fonction : Auteur
Elsa Baumeister
  • Fonction : Auteur
Sonia Mara Raboni
  • Fonction : Auteur
Heloisa Giamberardino
  • Fonction : Auteur
Doris Gomez
Parvaiz Koul
  • Fonction : Auteur
Nancy Otieno
  • Fonction : Auteur
Maria Lourdes Guerrero Almeida
  • Fonction : Auteur
Victor Alberto Laguna-Torres
  • Fonction : Auteur
Anca Cristina Drăgănescu
  • Fonction : Auteur
Elena Burtseva
  • Fonction : Auteur
Anna Sominina
  • Fonction : Auteur
Daria Danilenko
  • Fonction : Auteur
Snežana Medić
  • Fonction : Auteur
Javier Diez-Domingo
  • Fonction : Auteur
Bruno Lina

Résumé

Background: The Global Influenza Hospital Surveillance Network (GIHSN) was established in 2012 to conduct coordinated worldwide influenza surveillance. In this study, we describe underlying comorbidities, symptoms, and outcomes in patients hospitalized with influenza. Methods: Between November 2018 and October 2019, GIHSN included 19 sites in 18 countries using a standardized surveillance protocol. Influenza infection was laboratory-confirmed with reverse-transcription polymerase chain reaction. A multivariate logistic regression model was utilized to analyze the extent to which various risk factors predict severe outcomes. Results: Of 16 022 enrolled patients, 21.9% had laboratory-confirmed influenza; 49.2% of influenza cases were A/H1N1pdm09. Fever and cough were the most common symptoms, although they decreased with age (P < .001). Shortness of breath was uncommon among those <50 years but increased with age (P < .001). Middle and older age and history of underlying diabetes or chronic obstructive pulmonary disease were associated with increased odds of death and intensive care unit (ICU) admission, and male sex and influenza vaccination were associated with lower odds. The ICU admissions and mortality occurred across the age spectrum. Conclusions: Both virus and host factors contributed to influenza burden. We identified age differences in comorbidities, presenting symptoms, and adverse clinical outcomes among those hospitalized with influenza and benefit from influenza vaccination in protecting against adverse clinical outcomes. The GIHSN provides an ongoing platform for global understanding of hospitalized influenza illness.
Fichier principal
Vignette du fichier
ofad244.pdf (619) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
licence

Dates et versions

hal-04906009 , version 1 (05-02-2025)

Licence

Identifiants

Citer

Melissa Andrew, Henrique Pott, Lisa Staadegaard, John Paget, Sandra Chaves, et al.. Age Differences in Comorbidities, Presenting Symptoms, and Outcomes of Influenza Illness Requiring Hospitalization: A Worldwide Perspective From the Global Influenza Hospital Surveillance Network. Open Forum Infectious Diseases, 2023, 10 (6), pp.ofad244. ⟨10.1093/ofid/ofad244⟩. ⟨hal-04906009⟩
3 Consultations
0 Téléchargements

Altmetric

Partager

More